Sepsis is primarily classified as which cause of AKI?

Sepsis is primarily classified as an intra-renal cause of acute kidney injury (AKI). Intra-renal AKI refers to damage that occurs within the kidney itself, which can result from various factors including infections like sepsis. During sepsis, the body experiences a systemic inflammatory response that can lead to hemodynamic changes, reduced blood flow, and direct kidney damage from toxins released by pathogens. This combination can impair the renal tubules and glomeruli, contributing to acute kidney injury.

Understanding that sepsis leads to intra-renal damage is crucial for appropriate management of patients experiencing AKI, as it highlights the need for targeted interventions focused on treating the underlying infection and supporting kidney function, rather than simply addressing pre-renal or post-renal factors.